Angela Fitch’s household historical past of weight problems caught as much as her at age 40, when she was pregnant along with her first youngster.

As a doctor and weight problems medication specialist, Dr. Fitch knew the life-style levers to drag—and he or she had the monetary means to yank them arduous.

After giving beginning, she lifted weights with a coach twice every week. She sweated via one Peloton exercise after one other and tracked her meals consumption on MyFitnessPal.

However, for the following decade, Dr. Fitch misplaced (and regained) the identical 5 to 10 kilos. Her blood strain crept upward. Then got here a sleep apnea analysis.

As her fiftieth birthday neared, Dr. Fitch determined to take the recommendation she gave her sufferers. She went on remedy. (And, she misplaced 30 kilos.)

Within the years since, Dr. Fitch has often stopped her meds. For a number of months, she maintains her outcomes.

Ultimately, nevertheless, the size climbs again. For now, she’s determined that she’ll be on remedy long-term.

When you’re a coach, how does this story land with you?

Does it…

Make you’re feeling disillusioned? Does this seem to be a narrative of somebody “giving up” or “not making an attempt arduous sufficient”?

Encourage you with a way of awe? That fashionable medication has found out methods to deal with one more persistent illness?

Deliver up questions? Like questioning in regards to the results of being on remedy—probably long-term? (Or if weight reduction is even that related—as long as an individual is maintaining a healthy diet and exercising frequently?)

Dr. Fitch is now president of the Weight problems Drugs Affiliation and chief medical officer of Identified Properly, a major care and weight problems medication observe in Needham, Massachusetts. No matter how you’re feeling about her story, it illustrates what can initially seem to be an inconvenient reality for these of us within the well being teaching trade:

Conduct change by itself isn’t all the time sufficient.

For many individuals with weight problems, semaglutide (Ozempic, Wegovy, Rebelsus), tirzepatide (Mounjaro, Zepbound), and different glucagon-like peptide-1 receptor agonists (GLP-1 RAs) function worthwhile instruments that make vital and lasting weight reduction doable.

However for well being coaches, these medication can seem to be an existential risk.

You would possibly surprise:

‘Who wants a vitamin coach or a private coach when folks can get quicker, simpler, and extra dramatic outcomes with medication?’


Folks want well being coaches now greater than ever.

On this story, we’ll clarify why—and present you methods to flip “the golden age of weight problems medication” into an enormous profession alternative.

With fats loss, there’s no such factor as an “simple method out.”

To handle diabetes or deal with most cancers, most individuals contemplate it regular and pure to mix life-style behaviors with prescription medication.

Nobody would inform somebody with most cancers, “You’re on chemo? Approach to take the simple method out!”

Nonetheless, that’s what many individuals with weight problems hear after they point out remedy or surgical procedure.

For many years, a lot of society hasn’t considered weight problems because the illness that it’s.

As an alternative, folks have seen it as a willpower drawback.

The treatment: “Simply attempt more durable.”

Nonetheless, slightly than motivating folks to succeed, this “treatment” typically encourages them to surrender. (Extra importantly, the willpower principle isn’t based mostly on science.)

In actuality, folks with weight problems doubtless have as a lot willpower as anybody else.

Nonetheless, for them, fats loss is more durable—due to genetics and physiology, together with social, cultural, behavioral, and/or environmental elements that work in opposition to them.

Why is it so tough to lose fats?

Think about life 150 years in the past, earlier than the invention of the car. To get from level A to level B, you needed to stroll, pedal a bicycle, or experience a horse.

Meals was typically briefly provide, too. You needed to expend energy to get it, and meals would simply fulfill you (however not depart you feeling “full”).

Immediately, nevertheless…

“We reside in an obesogenic surroundings that’s crammed with low cost, highly-palatable, energy-dense meals [that make overeating calories easy, often unconsciously], and numerous conveniences that scale back our bodily exercise,”
says Karl Nadolsky, MD, an endocrinologist and weight reduction specialist at Holland Hospital and co-host of the Docs Who Elevate podcast.

You would possibly surprise: Why do some folks acquire fats in an obesity-promoting surroundings whereas others don’t?

The reply comes right down to, largely, genetics and physiology.

(Weight problems is advanced and multifactorial. As we famous above, there are different influential elements, however your genes and physiology are largely out of your management, and so remedy could be the perfect software to change their influence.)

Genetically, some persons are extra predisposed to weight problems.

Some genes can result in extreme weight problems at a really early age. Nonetheless, these are fairly uncommon.

Way more widespread is polygenic weight problems—when two or extra genes work collectively to predispose you to weight acquire, particularly whenever you’re uncovered to the obesogenic surroundings talked about earlier.

Individuals who inherit a number of of those so-called weight problems genes are inclined to have notably persistent “I’m hungry” and “I’m not full but” indicators, says Dr. Nadolsky.

Weight problems genes additionally appear to trigger some folks to expertise what’s colloquially often known as “meals noise.”

They really feel obsessive about meals, regularly considering, “What am I going to eat subsequent? When is my subsequent meal? Can I eat now?

Physiologically, our bodies have a tendency to withstand fats loss.

When you acquire a number of fats, the hormones in your intestine, fats cells, and mind can change the way you expertise starvation and fullness.

“It’s like a thermostat in a home, however now it’s damaged,” says Dr. Nadolsky. “So when folks minimize energy and weight goes down, these physiologic elements work in opposition to them.”

After reducing weight, your intestine might regularly ship out the “I’m hungry” sign, even should you’ve lately eaten, and even if in case you have greater than sufficient physique fats to function a calorie reserve. It additionally would possibly take extra meals so that you can really feel full than, say, another person who’s by no means been at the next weight.

Enter: GLP-1 medication

In 2017, semaglutide—an artificial analog of the metabolic hormone glucagon-like peptide 1—was authorised within the US as an antidiabetic and anti-obesity remedy.

With the emergence of this class of medicine, science provided folks with weight problems a comparatively secure and accessible method to shed pounds long-term, as long as they continued the remedy.

How Ozempic and different weight problems medicines work

Present weight reduction drugs work primarily by mimicking the perform of glucagon-like peptide 1 (GLP-1), which is a hormone that performs a number of capabilities:

  • Within the pancreas, it triggers insulin secretion, which helps regulate blood sugar.
  • Within the intestine, it slows gastric emptying, affecting your sensation of fullness.
  • Within the mind, it reduces cravings (the need for particular meals) and meals noise (intrusive ideas about meals).

In folks with weight problems, the physique shortly breaks down endogenous (pure) GLP-1, making it much less efficient. In consequence, it takes longer to really feel full, meals provide much less endurance, and meals noise turns into a near-constant companion, says Dr. Nadolsky.

Semaglutide (Ozempic, Wegovy, Rybelsus) and medicines prefer it flood the physique with synthetically made GLP-1 that lasts for much longer than the GLP-1 the physique produces. This long-lasting impact helps enhance emotions of fullness, scale back between-meal starvation, and muffle cravings and meals noise.

Apparently, by calming down the mind’s reward heart, these medicines might also assist folks scale back addictive behaviors like drawback consuming and compulsive playing, says Dr. Nadolsky.

The lesser-known historical past of weight reduction medication

To know the ability of semaglutide (Ozempic, Wegovy, Rybelsus) and different GLP-1 medicines, it’s useful to know a little bit in regards to the medication that predated it.

Many years earlier than the age of Ozempic, physicians realized that a number of medication initially developed to deal with different circumstances additionally appeared to assist folks shed pounds.

These included:

  • Qsymia, which pairs phentermine (an older weight reduction medication) with the epilepsy medication topiramate
  • Contrave, which mixes the antidepressant bupropion (Wellbutrin) with naltrexone, used to deal with addictions
  • Metformin, a diabetes medication

Nonetheless, weight reduction from these older medicines was modest, serving to folks to lose (and preserve off) round 5 to 10 % of their physique weight.1 2 3

Round 2010, liraglutide (Victoza, Saxenda) was authorised by the FDA to deal with diabetes. Like Ozempic and different newer weight reduction medicines, liraglutide mimics glucagon-like peptide-1 (GLP-1), however it’s much less efficient than the newer medicines.

Why does Ozempic get all of the credit score?

Ozempic has turn out to be the Kleenex of weight reduction medicines—a reputation model folks toss round as if it’s generic.

This fame is a minimum of partly earned: Dr. Fitch says that semaglutide (Ozempic, Rybelsus, Wegovy) additionally works extra successfully than liraglutide, its GLP-1 predecessor.

“Semaglutide is 94 % just like our personal GLP-1,” she says, “They’ve been in a position to make it nearer and nearer to the GLP-1 our our bodies make.”

It additionally lasts longer than liraglutide, and extra of it reaches the mind.

Nonetheless, newer meds outperform Ozempic. (See the desk within the part beneath.)

And there are different medicines—obtainable orally slightly than through injection—coming. These capsules will likely be simpler to mass produce, which can drive down prices and make GLP-1 medicines much more accessible to extra folks.

So, though Ozempic is the present reigning model of the burden loss drug world, it might be ousted in time.

The rising effectiveness of weight reduction medication (particularly together with life-style modifications)

Researchers measure a weight-loss medication’s success based mostly on the share of people that attain key weight reduction milestones.

For instance, most individuals begin to see well being advantages after dropping 5 % of their weight—and remission from illness after dropping round 20 %.

Because the chart beneath exhibits, weight reduction medicines have turn out to be more and more efficient at serving to folks to succeed in each milestones.

Drugs % of people that lose 5% of their weight % of people that lose >20% of their weight
First-generation weight reduction medicines (Qsymia, Contrave, Metformin) 4 5 6 53-80% 10-20%
Semaglutide (Ozempic, Rybelsus, Wegovy) 7 8 86% 32%
Tirzepatide (Mounjaro, Zepbound) 9 10 85-91% 50-57%
Retatrutide (not but FDA authorised) 11 12 92-100% 80-83%

How do weight reduction drugs evaluate to conventional interventions?

Prior to now, weight reduction interventions have centered on life-style modifications like calorie or macronutrient manipulation, train, and generally counseling.

Slightly than pitting life-style modifications in opposition to weight reduction medicines or surgical procedure, it’s extra useful to consider all of them as instruments.

Because the graph beneath exhibits, the extra weight reduction instruments somebody makes use of—together with teaching—the extra vital the outcomes.13 14 15 16

Bar graph compares five common weight loss tools: Lifestyle plus coaching; Lifestyle plus Semaglutide; Lifestyle plus Tirzepatide; Lifestyle plus Retatrutide; and Lifestyle plus Bariatric Surgery. Lifestyle plus coaching yeilds the lowest weight lost, with people losing, on average, five to 13 percent of their body weight. Lifestyle plus Bariatric Surgery yeilds the highest weight lost, with people losing, on average, over 30 percent of their body weight. Lifestyle plus medications tend to yeild losses between 15 and 25 percent of body weight.

Fats loss typically comes with highly effective well being advantages

For years, the medical group has informed of us that dropping 5 to 10 % of their physique weight was ok.

Partly, this message was designed to right-set folks’s expectations, as few lose rather more than that (and preserve it off) with life-style modifications alone.

As well as, this modest weight reduction additionally results in measurable well being enhancements. Lose 5 to 10 % of your whole weight, and also you’ll begin to see blood sugar, ldl cholesterol, and strain drop.17

Nonetheless, dropping 15 to twenty % of your weight, as folks are inclined to do after they mix life-style modifications with second-generation GLP-1s, and also you do rather more than enhance your well being. You possibly can go into remission for a number of well being issues, together with:

  • Hypertension
  • Diabetes
  • Fatty liver illness
  • Sleep apnea

Meaning, by taking a GLP-1 medication, you would possibly have the ability ultimately to cease taking a number of different medication, says Dr. Nadolsky.

Consultants suspect GLP-1s might enhance well being even when no weight reduction happens.

“The medicines appear to supply additive advantages past simply weight discount,” says Dr. Nadolsky.

Analysis signifies that GLP-1s might scale back the chance of main cardiovascular occasions (coronary heart assaults and strokes) in folks with diabetes or coronary heart illness.18 19 20 In folks with diabetes, they appear to enhance kidney perform, too.21

The idea is that organs all through the physique have GLP-1 receptors on their cells. When the GLP-1s connect to those receptors within the kidneys and coronary heart, they appear to guard these organs from injury.

Because of this, in 2023, the American Coronary heart Affiliation listed GLP-1 receptor agonists as one of many yr’s prime advances in heart problems.

Ozempic unwanted effects

You’ve doubtless heard that slowed gastric emptying from GLP-1s can result in nausea, constipation, and different GI woes.

That’s all true.

Nonetheless, for many, these unwanted effects are manageable, particularly with the assistance of some key methods (which we’ll cowl later).

For now, nevertheless, we’d prefer to hash out a selected draw back you’ve doubtless heard about from the media—as a result of it presents an enormous alternative for well being coaches.

When folks take GLP-1 weight reduction medicines, about 30 to 40 % of the burden they lose can come from lean mass.22 23 24

Put one other method: For each 10 kilos somebody loses, about six to seven come from fats and three to 4 from muscle, bone, and different non-fat tissues.

This statistic has been broadcast amongst many media shops in current weeks as a dire warning in opposition to taking Ozempic, Wegovy, or Zepbound.

Such tales typically fail to say two essential caveats:

Caveat #1: Folks with extreme weight problems usually have extra muscle and bone mass than others.

To know why, think about you had been pressured to put on a 100- or 200-pound physique swimsuit each day for a yr. On a regular basis actions—getting out and in of chairs, strolling to and from the mailbox, climbing steps right into a constructing—would really feel like a resistance exercise.

That’s doubtless partly why bariatric surgical procedure sufferers expertise a nine-year extension on their life expectancy, regardless of 30 % of their weight reduction coming from lean mass. They’ve extra muscle than common to start with, and due to this fact can safely lose some.25 26

For folks with extreme weight problems, the well being increase from physique fats loss offsets the well being danger of muscle and bone loss, says Dr. Fitch.

That stated, there’s a caveat to the caveat: People who find themselves solely 30 kilos or so chubby might not be beginning out with muscle and bone mass to spare. Particularly in the event that they’re older, they could start their weight reduction journey already under-muscled, with comparatively low bone density. In these folks, one other drop in lean mass and bone density can add as much as huge well being issues.


Caveat #2: Muscle and bone loss aren’t inevitable.

As Dr. Nadolsky places it, “Muscle loss isn’t a motive to keep away from treating weight problems [with medication]. It’s a motive to do extra train.”

That is the place coaches can shine.

By displaying shoppers methods to undertake muscle-building behaviors like energy coaching, mixed with enough protein consumption, you’ll be able to assist folks offset the worst of the unwanted effects when taking these medicines.

The yo-yo drawback

GLP-1s are costly, costing roughly $1000 USD a month. In consequence, many insurers both refuse to cowl them or restrict their protection to a yr or two.

As soon as the cash runs out, folks are inclined to go off the meds—and the starvation and cravings return.

In the event that they’ve performed little to vary their foundational consuming habits, this places them at a big drawback. In the event that they’re not consuming slowly and mindfully and enhancing satiety with veggies and lean protein, the return of starvation and meals noise might be overpowering.

That’s doubtless why, in a single examine, members who stopped taking semaglutide regained, on common, two-thirds of the burden they’d misplaced.27

Line graph shows that people who take semaglutide will regain, on average, about two-thirds of the weight they lose within a year of discontinuing medication.

Once more, right here’s one other alternative for coaches…

Use weight reduction medication as a key that unlocks life-style modifications.

Weight reduction medicines don’t render behavior-based methods out of date; they make them extra important.

When GLP-1 medicines muffle meals noise and starvation, your consumer will discover it simpler to prioritize protein, fruits and veggies, legumes, and different minimally processed complete meals. Equally, as the size goes down, shoppers really feel higher, so that they’re extra more likely to embrace weight lifting and do different types of train.

In response to a 2024 shopper tendencies survey, 41 % of GLP-1 medication customers reported that their train frequency elevated since happening the remedy. The vast majority of them additionally reported an enchancment in weight-reduction plan high quality, selecting to eat extra protein, in addition to fruit and veggies.28

That is nice information, as a result of, as talked about above, life-style modifications are important to preserving lean mass and stopping regain, ought to shoppers select to discontinue remedy.

When working with shoppers on GLP-1s, preserve the next challenges in thoughts.

Teaching technique #1: Discover methods to eat nutritiously regardless of unwanted effects.

The slowed abdomen emptying attributable to GLP-1 medication can set off nausea and constipation.

Luckily, for most individuals, these GI woes are inclined to resolve inside a number of weeks.

Nonetheless, should you’re working with a consumer who’s experiencing a number of nausea, they gained’t doubtless welcome salads into their lives with open arms. (Consider how you’re feeling when you could have the abdomen flu. A bowl of roughage doesn’t seem to be it’ll “go down simple.”)

As an alternative, assist shoppers discover extra palatable methods to devour nutritious meals. (For instance, fruit and veggies within the type of a smoothie or pureed soup could be simpler.)

Dr. Nadolsky additionally suggests folks keep away from the next widespread offenders:

  • Massive parts of any sort
  • Greasy, fatty meals
  • Extremely processed meals
  • Any robust meals smells that set off a consumer’s gag reflex
  • Sugar alcohols (like xylitol, erythritol, maltitol, and sorbitol, typically present in weight-reduction plan sodas, chewing gum, and low-sugar protein bars), which may set off diarrhea in some

Teaching technique #2: Prioritize energy coaching.

To protect muscle mass, intention for a minimum of two full-body resistance coaching classes every week.

As well as, transfer round as a lot as you’ll be able to. Strolling and different types of bodily exercise are important for preserving the burden off—and may help to maneuver meals via the intestine to ease digestion.29 30

(Want inspiration for energy coaching? Take a look at our free train video library.)

Teaching technique #3: Lean into lean protein.

Along with energy coaching, protein is important for serving to to guard muscle mass.

You need to use our free macros calculator to find out the correct quantity of protein for you or your consumer. (Spoiler: Most individuals will want 1 to 2 palm-sized protein parts per meal, or about 0.5 to 1 gram of protein per pound of body weight per day.)

Teaching technique #4: Fill your plate with fruit and veggies.

Apart from being good on your total well being, complete, recent, and frozen produce fuels you with important vitamins that may assist drive down ranges of irritation.

Along with elevating your danger for illness, persistent irritation can block protein synthesis, making it more durable to take care of muscle mass.

(Didn’t know managing irritation issues in the case of preserving muscle? Discover out extra muscle-supporting methods right here: Learn how to construct muscle energy, dimension, and energy)

Teaching technique #5: Select high-fiber carbs over low-fiber carbs.

Beans, lentils, complete grains, and starchy tubers like potatoes and candy potatoes usually tend to assist shoppers really feel full and handle blood sugar than lower-fiber, extra extremely processed choices.

(Learn extra in regards to the drawbacks—and occasional advantages—of processed meals right here: Minimally processed vs. extremely processed meals.)

Teaching technique #6: Select wholesome fat.

Wholesome fat may help you’re feeling full between meals and defend your total well being. Gravitate towards fat from complete meals like avocado, fatty fish (which can be a protein!), seeds, nuts, and olive oil—utilizing them to interchange much less wholesome fat from extremely processed meals.

(Unsure which fat are wholesome? Use our 3-step information for selecting the perfect meals on your physique.)

Teaching technique #7: Construct resilient habits.

It might go with out saying, however the above ideas are simply the beginning.

(There’s additionally: high quality sleep, social assist, stress administration, and extra.)

Most significantly, shoppers want your assist to make the entire above simpler and extra automated.

And that’s the actual present of teaching: You’re not merely serving to shoppers determine what to eat and methods to transfer; You’re displaying them methods to take away boundaries and create techniques and routines so their highway to well being is a little bit smoother.

That method, in the event that they do have to cease taking remedy, their ingrained life-style habits (that the medication made simpler for them to undertake) will make it extra doubtless that they preserve their outcomes.


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